Table 5.
Overview of genetic association studies related to salty taste preferences.
| Gene | SNP | Applied tastant/method | Number of studies with confirmed association | Findings | Reference | Number of studies with no association | Reference |
|---|---|---|---|---|---|---|---|
| TRPV1 | rs8065080 | NaCl | 1 | CC genotype significantly lower iAUCs | (Dias et al., 2013) | 0 | – |
| SCNN1B | rs239345 | NaCl | 1 | AA genotype significantly lower iAUCs | (Dias et al., 2013) | 0 | – |
| SCNN1B | rs3785368 | NaCl | 1 | TT genotype significantly lower iAUCs | (Dias et al., 2013) | 0 | – |
| CA6 | rs3737665 | NaCl, KCl | 1 | The SNP associated with differences in the perceived intensity of NaCl and KCl saltiness | (Feeney and Hayes, 2014) | 0 | – |
| CA6 | rs3765964 | NaCl | 1 | The SNP associated with differences in the perceived intensity of NaCl | (Feeney and Hayes, 2014) | 0 | – |
| CA6 | rs2274333 | KCl | 1 | The SNP associated with differences in KCl saltiness | (Feeney and Hayes, 2014) | 0 | – |
| TAS1R1 | rs17492553 | NaCl | 1 | T (allele, genotype) lower intensities | (Rawal et al., 2013) | 0 | – |
| TAS1R1 | rs34160967 | NaCl | 1 | A (allele, genotype) lower intensities | (Rawal et al., 2013) | 0 | – |
| TAS2R38 | A49P (rs713598), A262V (rs1726866), V296I (rs10246939) | NaCl | 1 | PAV/PAV higher ratings for saltiness intensity | (Deshaware and Singhal, 2017) | 1 | (Hayes et al., 2008) |
NaCl, sodium chloride; KCl, potassium chloride; iAUC, incremental area under the curve.
Individual ratings of the intensity of suprathreshold solutions were plotted, and the incremental area under the taste sensitivity curve (iAUC) was computed.