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. 2019 Dec 19;9:1407. doi: 10.3389/fonc.2019.01407

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Copyright © 2019 Yu, Li, Liu, Yang, Liu and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic diagram of RNA m⁶A methylation. The methyltransferase complex (METTL3, METTL14, WTAP, and METTL16), which catalyzes methylation at the N6 position adenosine, and the demethylases (FTO and ALKBH5), which remove methyl groups, dynamically regulate cellular m⁶A levels in the nucleus. Besides, m⁶A modification could be specifically recognized and bound by diverse reader proteins. Nuclear m⁶A readers promote miRNA processing while affecting mRNA splicing, stability, and export. Cytoplasmic readers mediate m⁶A-marked mRNA translation and degradation.