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. 2019 Dec 19;10:1528. doi: 10.3389/fphys.2019.01528

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Copyright © 2019 Li, Zhan, Yang, Feng, Zou, Lei, Zhao, Wang and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of XSEC or EE and their combination on the infarct volume in MCAO rats. (A) Representative axial T2 images (bregma –7.6 to –3.6 mm) obtained from various group rats on the 31^st day after MCAO. The infarct tissues were surrounded by red dotted lines. (B) Typical 3D reconstruction images of ischemic lesion were acquired by 3D Slicer software (purple region indicated the infarction). (C,D) Quantitative analysis of the infarct volume and the ratio of residual volume, respectively (one-way ANOVA followed by Bonferroni’s post hoc test, n = 8 per group). ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001 vs. vehicle group. ^∧P < 0.05, ^∧∧∧P < 0.001 vs. XSEC + EE group.