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. 2019 Dec 19;10:1528. doi: 10.3389/fphys.2019.01528

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Copyright © 2019 Li, Zhan, Yang, Feng, Zou, Lei, Zhao, Wang and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of XSEC or EE and their combination on the axonal microstructural changes in MCAO rats. (A) Representative DEC, AD, RD maps (bregma –0.6 mm) were obtained from various group rats on the 31^st day after MCAO. ROIs of the cortex (CTX), striatum (STR), and external capsule (EC) were identified on the DEC map. (B) Quantitative analysis of the relative FA, AD, and RD in the ipsilateral cortex, striatum and external capsule (one-way ANOVA followed by Bonferroni’s post hoc test, n = 8 per group). ^##P < 0.01, ^###P < 0.001 vs. control group. ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001 vs. vehicle group. ^∧P < 0.05 vs. XSEC + EE group.