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. 2019 Dec 19;10:1528. doi: 10.3389/fphys.2019.01528

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Copyright © 2019 Li, Zhan, Yang, Feng, Zou, Lei, Zhao, Wang and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of XSEC or EE and their combination on the myelinated axons in MCAO rats. (A) Typical LFB staining photographs showing the alterations of myelin sheath in the ipsilateral cortex, striatum and external capsule. ROIs of the peri-infarct cortex (CTX, red boxes), striatum (STR, yellow boxes), and external capsule (EC, dashed line) were indicated in the representative LFB map from a XSEC + EE treated rat. Remarkable cavitation areas (stars) and partial loss of myelin sheaths (arrows) in the axonal tracts were observed. (B) Quantitative data of the relative IOD of LFB in the ipsilateral cortex, striatum and external capsule (one-way ANOVA followed by Bonferroni’s post hoc test, n = 4 per group). ^###P < 0.001 vs. control group. ^∗∗∗P < 0.001 vs. vehicle group. ^∧∧P < 0.01 vs. XSEC + EE group.