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. 2019 Dec 19;10:1528. doi: 10.3389/fphys.2019.01528

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Copyright © 2019 Li, Zhan, Yang, Feng, Zou, Lei, Zhao, Wang and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of XSEC or EE and their combination on oligodendrogenesis in MCAO rats. (A) A representative coronal T2WI image at the level of bregma 0.2 mm. Boxes indicated the peri-infarct cortex and striatum where images were taken. (B) Representative images showing the co-expressed cells of Ki67⁺/NG2⁺ and Ki67⁺/CNPase⁺. (C) Quantitative data of the number of Ki67⁺/NG2⁺ and Ki67⁺/CNPase⁺ co-expressed cells in the peri-infarct cortex and striatum. (D,E) Representative images of Ki67/NG2 and Ki67/CNPase double immunofluorescent staining in the peri-infarct cortex and striatum. (F,G) Quantitative analysis of the protein and mRNA level of NG2 and CNPase in the peri-infarct brain tissues, respectively (one-way ANOVA followed by Bonferroni’s post hoc test, n = 4 per group). ^##P < 0.01 vs. control group. ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001 vs. vehicle group. ^∧P < 0.05, ^∧∧P < 0.01, ^∧∧∧P < 0.001 vs. XSEC + EE group.