Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Dec 19;10:2847. doi: 10.3389/fmicb.2019.02847

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 da Silva, Karlyshev, Oldfield, Wooldridge, Bayliss, Ryan and Griffin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Model pathway for translocation, processing, sorting, and export of FHbp in Neisseria meningitidis. Preprolipoproteins are synthesized in the cytoplasm and as they emerge from ribosomes bind chaperones such as SecA, which translocate them across the IM via SecYEG. Lgt disacylates the preprolipoprotein at the conserved C residue of the lipobox of the SP, next LspA cleaves the SP exposing the C residue for further acylation by Lnt (da Silva et al., 2017). The Lol apparatus (LolFD) in N. meningitidis sorts the triacylated lipoprotein to the OM by delivering this to chaperone LolA, which releases the mature lipoprotein to the OM lipoprotein acceptor, LolB (da Silva et al., 2017). SLAM then localizes FHbp to the cell surface (Hooda et al., 2016).