Table 3.
Combined Risk Genotypes of the Four Validated SNPs and Risk of BC in the DRIVE Study
| Genotype | Univariate analysis |
Multivariate analysis2 |
||||
|---|---|---|---|---|---|---|
| NControl/NCase | OR (95% CI) | P | NControl/NCase | OR (95% CI) | P | |
| NUG1 | ||||||
| 0 | 854/877 | ref. | 852/877 | ref. | ||
| 1 | 5268/5769 | 1.07 (0.96–1.18) | 0.2139 | 5252/5769 | 1.07 (0.97–1.19) | 0.1805 |
| 2 | 10067/11776 | 1.14 (1.03–1.26) | 0.0091 | 10024/11776 | 1.15 (1.04–1.27) | 0.0057 |
| 3 | 6734/8365 | 1.21 (1.10–1.34) | 0.0002 | 6705/8365 | 1.22 (1.10–1.35) | <0.0001 |
| 4 | 1417/1962 | 1.35 (1.20–1.52) | <0.0001 | 1412/1962 | 1.36 (1.21–1.53) | <0.0001 |
| Trend | <0.0001 | <0.0001 | ||||
| 0–2 | 16189/18422 | ref. | 16128/18422 | ref. | ||
| 3–4 | 8151/10327 | 1.11 (1.07–1.15) | <0.0001 | 8117/10327 | 1.12 (1.08–1.16) | <0.0001 |
Abbreviations: SNPs: single nucleotide polymorphisms; BC: breast cancer; DRIVE: Discovery, Biology, and Risk of Inherited Variants in Breast Cancer; NUG: number of unfavorable genotypes; OR: odd ratio; CI: confidence interval.
1
Risk genotypes were rs1323697 GC+CC, rs1264308 CC, rs141308737 C-/-- and rs1469412 TT.
2
Multivariate logistic regression analyses were adjusted for age and PCs.