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Potential sites of action of Dupilumab in inhibiting allergic inflammation. Dupilumab can act to inhibit TH2 cell differentiation, the transformation of Treg cells into ex-Treg cells in the context of allergic inflammation, and IgE production by B cells, driven by T follicular helper (TFH)- derived IL-4. It can also prevent IL-4-related vascular endothelium dysfunction. Furthermore, it can inhibit ILC2 induction via eosinophils and basophils.
