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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Expert Rev Neurother. 2019 Sep 26;20(1):85–93. doi: 10.1080/14737175.2020.1671824

Table 1.

Studies included in the final review.

First author, year Country Treatments N Treatment duration (sessions) Age M(SD) or range Study Design Assessment of IGD Inclusion Criteria; Type of Measure Primary Outcome Variable(s) Significant Results (follow-up timeframe)
Medication
Bae, 201821 South Korea Bupropion 15 12wks 25.3±5.2 Pre-post*~ DSM-5 criteria; measure based on SCID-I; diagnostic interview IGD symptoms (YIAS) Decrease in YIAS (post-treatment)
Han, 201020 South Korea Bupropion 11 6wks 21.5±5.6 Pre-post* YIAS>50 + gaming >30 hr/wk + distress or impairment ; self-report Weekly gaming (hrs); IGD symptoms (YIAS) Decrease in gaming time and YIAS (post-treatment)
Han, 200914 South Korea Methylphenidate
62

8wks

9.3±2.2
Pre-post** Video game playing was the only criteria; self-report Weekly gaming (hrs); IGD symptoms (YIAS) Decrease in gaming time and YIAS (post-treatment)
Nam, 201715 South Korea Bupropion
Escitalopram
15
15
12wks
12wks
22.9±1.9
23.9±1.6
RT, no control group** YIAS>50 + gaming > 4hrs/day or 30hrs/wk + distress or impairment; self-report IGD symptoms (YIAS) Decreased YIAS in both groups; no significant differences between groups (post-treatment)
Park, 2016a16 South Korea Atomoxetine
Methylphenidate
42

44
12wks

12wks
17.1±1.0

16.9±1.6
RT, no control group** DSM-5 criteria; specific measure not specified IGD symptoms (YIAS) Decreased YIAS in both groups but a test statistic for pre-post changes was not presented; no significant differences between groups (post-treatment)
Han, 2012b22 South Korea Bupropion+education
Placebo+education

25

25

8wks

8wks

21.2±8.0

19.1±6.2
RCT*** YIAS>50 + gaming >30 hrs/wk + distress or impairment; self-report Weekly gaming (hrs); IGD symptoms (YIAS) Greater reductions in gaming time and YIAS in the bupropion compared to placebo group (post-treatment)
Reductions and group differences maintained at follow-up (4 wks post-treatment)
Song, 201623 South Korea Bupropion
Escitalopram
No Treatment Control
44
42

33
6wks
6wks

6wks
20.0±3.6
19.8±4.2

19.6±4.0
RCT DSM-5 criteria, no specific measure identified; diagnosed by a psychiatrist IGD symptoms (YIAS) Decreased YIAS for active groups, but not control. Greater decrease for bupropion than escitalopram (post-treatment)
CBT-based Psychotherapy
Yao, 201725 China Group Reality & Mindfulness Therapy 25 6wks (6) 22.2±1.6 Pre-post* At least 5 DSM-5 criteria + ≥14 hr/wk of gaming + gaming was primary Internet activity; diagnostic interview IGD symptoms (CIAS) Decrease in CIAS (post-treatment)
González-Bueso, 201818 Spain Individual CBT
Individual CBT + Parent Psychoed
15

15
(12)

(12 ind + 6 parent)
15.5(2.3)

16.1(2.2)
Non-RCT* DQVMIA and SCID-I adapted to assess IGD; self-report and diagnostic interview IGD symptoms (DQVMIA) Decreased DQVMIA in both groups; no significant differences between groups (post-treatment)
Torres-Rodríguez, 201819 Spain Specialized CBT
Standard CBT

17
17

6mnth (22)
6mnth (22)

15.1(1.9)
14.7(1.6)
Non-RCT 5 or more DSM-5 symptoms and IGD-20 score≥71; self-report and diagnostic interview Weekly gaming (hrs); IGD symptoms (IGD-20) Fewer hours of gaming and IGD symptoms in treatment vs control group (post-treatment).
Differences were sustained but no between group comparison was presented (3 month follow-up)
Zhang, 2016b17†† China Craving behavioral intervention group
No intervention control

23

17

6wks(6)

N/A

21.9±1.8

22.0±1.9
Non-RCT CIAS ≥67 + gaming >14hr/wk for ≥1yr; plays 1 of 4 most popular game^; self-report Weekly gaming (hrs); IGD symptoms (CIAS) Lower CIAS and less gaming in intervention group than controls (post-treatment)
Li et al., 201326 China CBT group therapy
Basic counseling

14

14

6wks(12)

6wks(12)

12-19 yrs
RCT Gaming >30hr/wk + OGCAS >35 + IAS >3 + distress or maladaptive behavior; self-report and diagnosed by a psychiatrist IGD symptoms (YIAS) YIAS decreased in both groups but no group differences (post-treatment)
Li, 201724††† USA Mindfulness-oriented group therapy
Support group

15
15

8 wks(8)
8 wks(8)

22.2(3.8)
27.8(5.5)
RCT At least subthreshold IGD (≥3 DSM-5 symptoms [yes/no questions]); self-report Checklist based on DSM-5 IGD criteria (yes/no questions) Greater reduction in IGD symptoms in treatment vs support group (3 month post-treatment)
Kim, 201227 South Korea CBT+
Bupropion
Bupropion only

32
33

8wks(8)
8wks

16.2±1.4
15.9±1.6
RCT*** YIAS>50 + gaming >30hr/wk + maladaptive treatment or distress;
self-report
Weekly gaming time; IGD symptoms (YIAS) Greater reductions in gaming time and YIAS for CBT+med than med only group (post-treatment)

Group differences maintained at follow-up (4 wks post-treatment)
Park, 2016b28 South Korea CBT group therapy
Virtual Reality group therapy

12

12

4wks(8)

4wks(8)

24.2±3.2

23.6±2.7
RCT* Gaming >30hr/wk + disruption of life + distress or maladaptive treatment + YIAS>50; self-report IGD symptoms (YIAS) Both groups had reductions in YIAS but no between group differences (post-treatment)
Other Interventions
Han, 2012a29 South Korea Family therapy 15 3 wks(5) 14.2±1.5 Pre-post* Gaming >4hrs/day and >30hrs/wk + YIAS>50 + impaired treatment or distress;
self-report
Weekly gaming (hrs); IGD symptoms (YIAS) Decrease in gaming time and YIAS score (post-treatment)
King, 201730 Australia Brief voluntary abstinence 24 84 hours 24.6(5.1) Pre-post Current MMO player; only n=9 met criteria for IGD; self-report IGD symptoms (IGD checklist); Weekly gaming (hrs) Decrease between baseline and 28 day follow-up in IGD checklist for the entire sample (the 9 participants who met IGD criteria had greater declines in symptoms than non-IGD participants). No decrease in gaming time for the entire group (28 day follow-up) but meeting IGD criteria predicted greater decreases in gaming time.
Lee, 201831 South Korea Transcranial direct current stimulation 15 4 wks(12) 21.3±1.4 Pre-post* Two or more IGD symptoms or plays games an average of 1 hr/day or more; self-report IGD symptoms (YIAS); Weekly gaming (hrs) Decrease in YIAS and weekly gaming (post-treatment)
Palleson, 201532 Norway Eclectic psychotherapy (CBT, family, motivational interviewing, solution-focused) 12 (13) 15.7(1.3) Pre-post GASA ≥3 on all items and/or PVP score of 4 or 5 on all items; self-(GASA) and parent- (PVP) report IGD symptoms (self-reported GASA and PVP, parent-reported PVP) Decrease in parent-reported PVP but not self-reported GASA or PVP (post-treatment)
Sakuma, 201733 Japan Self-Discovery Camp 10 9 days 16.2±2.2 Pre-post Satisfied Griffith’s 6 components of addiction^^ + met DSM-V IGD criteria; diagnostic interview Daily gaming (hours) and weekly gaming (hours and days) Decrease in hours/day and hours/week of gaming but not days/week (3 months post-treatment)
Pornnoppoadol, 201834 Thailand Residential Camp (RC)
Parent management (PM)
RC + PM

Psychoed

24

24
26

30

7 days


(8)
7 days + 8 PM sessions 1 hour

14.6(1.4)

14.5(1.1)
14.0(1.4)

14.3(1.2)

Non-RCT
GAST-Parent version meeting the cut-off score; parent report IGD symptoms (GAST-parent report) Decrease in GAST in all four groups. All three active treatment groups superior to control at post-treatment and 6-month post-treatment.
Kim, 201335 South Korea MMORPG speaking and writing course
General education
27

32
8wks(21)

8wks(21)
17.4±0.6

17.5±0.6
RCT Playing DF ≥4hr/day; self-report Average daily gaming in the past month (minutes) Both groups showed reductions in gaming but no difference between groups (post-treatment)

Note. CBT = Cognitive Behavioral Therapy; CIAS = Chen Internet Addiction Scale; DF = Dungeon & Fighter; DQVMIA = Diagnostic Questionnaire for Video Games, Mobile Phone or Internet Addiction; GASA = Gaming Addiction Scale for Adolescents; GAST = Gaming Addiction Screening Test; IAS = Internet Addiction Scale; MMORPG = Massive Multiplayer Online Role-Playing Games; OGCAS = Online Game Cognitive Addiction Scale; PM = Parent Management; PVP = Problem Video Game Playing Scale; RCT = randomized control trial; RT = randomized trial; SCID-I = Structured Clinical Interview for DSM-IV; YIAS = Young Internet Addiction Scale.

*

a sample of healthy controls was recruited by not included in primary analyses of interest;

**

all participants had a diagnosis of attention deficit hyperactivity disorder;

***

all participants had a diagnosis of major depressive disorder;

~

a sample of patients with Internet-based gambling disorder was recruited but not reviewed here;

participants were randomly assigned to the two medication groups but the control group were participants who declined medication treatment (not randomly assigned).

††

similar results were presented in three other publications by the same authors42, 43, 44; the paper that presented on the largest sample size was chosen for inclusion.

†††

similar results were presented in a more recent publication not included here45.

^

participants reported playing one of the following games as their primary online activity: 1) Cross Fire; 2) Defense of the Ancient version 1; 3) Defense of the Ancient version 2; or 4) World of Warcraft.

^^

Griffith’s six components of addiction are salience, mood modification, tolerance, withdrawal, conflict, and relapse46.