Table 2.
Long noncoding RNAs in Parkinson's disease
| Long noncoding RNAs | Regions | Functions | References |
|---|---|---|---|
| LncRNA NEAT1 | MPTP mouse model and MPP+‐induced SH‐SY5Y | Regulating neuronal injury by targeting miR‐124; promoting autophagy through stabilizing PINK1 protein | 78, 100 |
| LncRNA HAGLROS | MPTP mouse model and MPP+‐induced SH‐SY5Y | Regulating apoptosis and autophagy via regulating miR‐100/ATG10 axis and PI3K/Akt/mTOR pathway activation | 79 |
| LncRNA HOTAIR | Midbrain tissue of MPTP induced PD mice and SH‐SY5Y cells exposed to MPP+ | Promoting PD by upregulating LRRK2 expression; targeting miR‐126‐5p to promote PD through RAB3IP | 83, 112 |
| LncRNA SNHG1 | SH‐SY5Y cells | Promoting α‐synuclein aggregation and toxicity by targeting miR‐15b‐5p to activate SIAH1 | 84 |
| LncRNA MALAT1 | MPTP mouse model and MPP+‐induced SH‐SY5Y; MN9D cells | α‐synuclein protein expression; regulating cell apoptosis by directly targeting LRRK2 through lncRNA MALAT1/miR‐205‐5p axis | 85, 98 |
| LncRNA UCA1 | Substantia nigra striatum of 6‐OHDA PD model; MPTP mouse model and MPP+‐induced SH‐SY5Y | The damage of dopaminergic neurons, oxidative stress and inflammation by the PI3K/Akt signaling pathway; promoting PD development by upregulating SNCA | 94, 99 |
| LncRNA‐p21 | SH‐SY5Y cells | Regulating MPP+‐induced neuronal injury by targeting miR‐625 and derepressing TRPM2 | 95 |
| Nrf2‐related lncRNAs | Substantia nigra of paraquat and MPTP induced mouse model | Oxidative stress | 96 |
| LncRNA AS Uchl1 | Dopaminergic cells' differentiation in vitro and in neurochemical models of PD | Expression is under the regulation of Nurr1 | 110 |
| PINK1‐AS, UCHL1‐AS, BCYRN1, SOX2‐OT, ANRIL and HAR1A | PD in the Hungarian population | Interfering with the binding affinity of transcription factor HNF4A, potentially resulting in abnormal expression of target genes, such as BCYRN1 | 111 |
| Sox2OT | Anti‐NGF AD11 transgenic mouse | Regulating cotranscribed Sox2 gene expression to down neurogenesis | 113 |