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. 2019 Dec 10;12:18–27. doi: 10.1016/j.ijpddr.2019.12.001

Fig. 2.

Fig. 2

Embryogenesis is inhibited by CBR417 and CBR490 treatment in the L. sigmodontisjird model. Embryonic stages (oocyte, morula, pretzel, stretched mf and degenerated embryos) per female adult worms isolated from jirds infected with L. sigmodontis that were treated with doxycycline (DOX), CBR417, CBR490, vehicle control or left untreated. A: 13-week-infected jirds were either left untreated or treated bi-daily (BID) with 40 mg/kg doxycycline for 14 days, once per day (QD) with 50 mg/kg CBR417 for 4 days or BID with 75 or 25 mg/kg CBR490 for 7 days. B: 16-week-infected jirds were either treated BID with vehicle control for 7 days, BID with 40 mg/kg doxycycline for 14 days, QD with 50 or 20 mg/kg CBR417 for 7 days, or QD with 10 mg/kg CBR490 for 7 days. Jirds were sacrificed 16 (A) or 18 (B) weeks after treatment. Analysis for statistical significance was done by Kruskal-Wallis followed by Dunn's multiple comparison post-hoc test.