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. 2019 Nov 26;17:83–98. doi: 10.1016/j.omtm.2019.11.013

Figure 4.

Figure 4

Non-toxic HSCT-Based Macrophage-Mediated GDNF Delivery Mitigated Progressive Motor Deficits and Non-motor Dysfunction in MitoPark Mice

(A) Spontaneous horizontal locomotor activities. (B) Spontaneous vertical locomotor activities. Each point represents mean ± SEM of 6 × 10 min test recorded from 15 animals per treatment group (n = 15). Two-way ANOVA was performed, followed by Bonferroni post-test. *p < 0.05, **p < 0.01, ***p < 0.001, Mito-LT-MSP-GFP versus Mito-LT-MSP-hGDNF-2A-GFP and Mito-LT-MSP-hGDNF groups. (C) Novel-object recognition. (D) Sucrose preference. Each bar represents mean ± SEM from 15 animals per treatment group (n = 15). Two-way ANOVA was performed, followed by Bonferroni post-test. *p < 0.05, **p < 0.01, ***p < 0.001, Mito-LT-MSP-GFP versus Mito-LT-MSP-hGDNF-2A-GFP and Mito-LT-MSP-hGDNF groups.