A doubly multivariate repeated-measures ANOVA of all three subdomains in FIS based on the same terms as in the repeated time laps of the treatment effect. Partial Eta Squared and (P-values) are corrected by the Greenhouse-Geisser method for all seven subdomains. Patient group (fresh and frozen donor FMT combined vs. placebo autologous FMT) combined with other functional disorders (patient group*depression) have significant effect in the subdomains interference with activity, body image and relationships. FIS = fatigue impact scale.