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. 2019 Oct 10;15:178–185. doi: 10.1016/j.omto.2019.10.002

Figure 3.

Figure 3

Correlating SPECT Imaging Data with Protein Expression (VSV and NIS Staining) or Cell Killing (TUNEL Staining for DNA Damage) in Tumor Sections

(A–E) MPC-11 tumors from BALB/c mice that received saline or 106 TCID50 VSV-mIFNβ-NIS were harvested on days 3 and 5. Representative images of tumor sections are shown. (A–C) 125I SPECT results at days 3 and 5 (A) are confirmed via IHC staining using anti-VSV antibody (B) and anti-hNIS antibody (C). (D and E) 99mTc SPECT results at days 3 and 5 (D) are confirmed using TUNEL assay (E).