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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Neurobiol Aging. 2019 Sep 9;83:114–121. doi: 10.1016/j.neurobiolaging.2019.09.001

Table 4.

Association of Alzheimer’s disease polygenic risk score with pupillary dilation response

Digit Span Load Estimate SE DF t p r
3 Digits (n=537) 0.003 0.007 139 0.42 .67 .02
6 Digits (n=530) 0.014 0.010 135 1.42 .16 .06
9 Digits (n=521) 0.023 0.010 130 2.18 .03 .10

Covariates include age, the first 3 principal components from the genome-wide genotyping data, pupillometry device, and total number of medications with anticholinergic properties. Data were restricted to cognitively normal individuals with a maximum digit span of 5–7 digits. Ns vary due to missing data for particular variables.