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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Neurobiol Aging. 2019 Sep 9;83:114–121. doi: 10.1016/j.neurobiolaging.2019.09.001

Table 5.

Association of Alzheimer’s disease polygenic risk score (upper vs. lower quartile) with pupillary dilation response

Digit Span Load Estimate SE DF t p d
3 Digits (n=272) −0.017 0.020 137 −0.86 .39 .10
6 Digits (n=267) −0.048 0.027 133 −1.79 .08 .22
9 Digits (n=264) −0.080 0.028 128 −2.88 .005 .36

Covariates include age, the first 3 principal components from the genome-wide genotyping data; pupillometry device, and total number of medications with anticholinergic properties. Data were restricted to cognitively normal individuals with a maximum digit span of 5–7 digits. Ns vary due to missing data for particular variables. Results presented represent the difference between the upper and lower quartiles of the AD-PRS distribution.