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. 2019 Sep 30;68(1):33–57. doi: 10.1369/0022155419878416

Figure 7.

Figure 7.

Fluorescence immunohistochemical staining showing p-EGFR and VEGFR2 expression in bone marrow (A–D) and glioblastoma (E–G). A fraction of CD150-positive HSCs in HSC niches express p-EGFR and VEGFR2 (A, C) as well as cells outside HSC niches (B, D). In glioblastoma, a fraction of CD133-positive GSCs in GSC niches express VEGFR2 (F) whereas all CD133-positive GSCs exress p-EGFR (G). Both p-EGFR and VEGFR2 are also expressed in other cell types in glioblastoma. VEGFR2 expression was found in cells in the arteriolar wall in bone marrow and glioblastoma (C, F). DAPI was used for nuclear counterstaining. Scale bar = 100 µm. Abbreviations: p-EGFR, phosphorylated epidermal growth factor receptor; VEGFR2, vascular endothelial growth factor receptor 2; HSC, hematopoietic stem cell; GSC, glioblastoma stem cell; DAPI, 4,’6-diamidino-2-phenylindole.