Table 5.
BRCA Mutations Associated Factors with Recurrence-free Survival
| Variable | N | Median | 95% Confidence interval |
P | |
|---|---|---|---|---|---|
| Lower bound | Upper bound | ||||
| RFS (months) | 179 | 47.7 | 40.4 | 55.0 | |
| BRCA status | 0.949 | ||||
| WT | 120 | 49.2 | 41.59 | 56.8 | |
| Mutated | 59 | 43.7 | 34.8 | 52.6 | |
| Type of BRCA mut | 0.030 | ||||
| BRCA1 | 39 | 37.6 | 29.0 | 46.2 | |
| BRCA2 | 20 | 72.77 | 38.37 | 107.17 | |
| BRCA location | 0.080 | ||||
| OCCR | 30 | 41.8 | 19.5 | 64.0 | |
| BCCR | 16 | 72.8 | 27.5 | 118.1 | |
| NRR | 13 | 40.1 | 19.4 | 60.7 | |
| Type of BRCA1 mut | 0.033 | ||||
| Endemic (exon 9–12 del) | 11 | 86.1 | 37.2 | 135.1 | |
| Other | 28 | 34.5 | 20.7 | 48.2 | |
| Type of BRCA2 mut | 0.442 | ||||
| c.8168 A > G | 5 | 72.8 | 51.9 | 93.6 | |
| Other | 15 | 62.3 | 19.2 | 105.3 | |
| BRCA1 location | 0.584 | ||||
| OCCR | 22 | 27.4 | 4.4 | 50.5 | |
| BCCR | 9 | 79.5 | 39.1 | 119.9 | |
| NRR | 8 | 40.1 | 25.7 | 54.4 | |
| BRCA2 location | 0.013 | ||||
| OCCR | 8 | NR | NR | NR | |
| BCCR | 7 | 72.8 | 39.0 | 106.6 | |
| NRR | 5 | 25.8 | 8.3 | 43.2 | |
OCCR = ovarian cancer cluster region; BCCR = breast cancer cluster region; NRR = not-related risk.