Figure 10.

Associations between genetic variants and age-related cortical morphological differences in the older subsample ( >60 years). Grayscale bar represents F-statistics. Areas in black-lightgray represent patterns at the exploratory level of q < 0.05. (A) Associations between APOE ε4 (risk for Alzheimer’s disease [AD]) and age-related CTh differences. Fitted age trajectories for 0 (solid lines), 1 (dashed lines), and 2 (circle, solid lines) ε4 alleles are depicted for vertices with maximum F-statistics in clusters (x-axis = age (years), y-axis = CTh adjusted for sex and intracranial volume). (B) Associations between BDNF Val66Met and age-related CVo differences. Fitted age trajectories for Val/Val (solid lines), Val/Met (dashed lines), and Met/Met genotypes (circle, solid lines) are depicted for vertices with maximum F-statistic in clusters. (C) Associations between COMT Val158Met and age-related CTh differences. Fitted age trajectories for Val/Val (solid lines), Val/Met (dashed lines), and Met/Met genotypes (circle, solid lines) are depicted for vertices with maximum F-statistics in clusters. (D) Associations of CASS4 rs7274581 (preventive for AD) and age-related CSA differences. Fitted age trajectories for T/T (solid lines), C/T (dashed lines), and C/C genotypes (circle, solid lines) are depicted for vertices with maximum F-statistics in clusters. (E) Associations between CD2AP rs10948363 (risk for AD) and age-related CSA differences. Fitted age trajectories for A/A (solid lines), A/G (dashed lines), and G/G genotypes (circle, solid lines) are depicted for vertices with maximum F-statistics in clusters.