Table 6.
Selectivities of 53 and 57 for β-Catenin/Tcf over β-Catenin/E-Cadherin and β-Catenin/APC Interactionsa
compounds | Ki ± SD (μM) | selectivity | |||
---|---|---|---|---|---|
β-catenin/Tcf | β-catenin/E-cadherin | β-catenin/APC | TCF/E-cadherin | TCF/APC | |
53 | 0.64 ± 0.12 | 32 ± 2.8 | 88 ± 7.3 | 50 | 137 |
57 | 0.44 ± 0.098 | 13 ± 0.60 | 173 ± 15 | 31 | 395 |
Each set of data was expressed as mean ± standard deviation (n = 3).