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. 2015 Nov 12;2015(11):CD009464. doi: 10.1002/14651858.CD009464.pub2

Comparison 1. Cannabinoid versus placebo.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1.1 Absence of nausea 2 96 Risk Ratio (IV, Random, 95% CI) 2.00 [0.19, 20.97]
1.2 Absence of vomiting 3 168 Risk Ratio (IV, Random, 95% CI) 5.69 [2.56, 12.64]
1.2.1 Nabilone 1 72 Risk Ratio (IV, Random, 95% CI) 7.25 [2.84, 18.52]
1.2.2 Dronabinol 2 96 Risk Ratio (IV, Random, 95% CI) 3.00 [0.65, 13.76]
1.3 Absence of nausea and vomiting 3 288 Risk Ratio (IV, Random, 95% CI) 2.86 [1.76, 4.65]
1.3.1 Cannabis naive 1 75 Risk Ratio (IV, Random, 95% CI) 2.23 [1.04, 4.78]
1.3.2 Prior cannabis use 2 213 Risk Ratio (IV, Random, 95% CI) 3.40 [1.80, 6.39]
1.4 Depression 1   Risk Ratio (IV, Random, 95% CI) Subtotals only
1.5 Dysphoria 2 96 Risk Ratio (IV, Random, 95% CI) 9.00 [0.50, 160.59]
1.6 'Feeling high' 3 137 Risk Ratio (IV, Random, 95% CI) 31.10 [6.37, 151.85]
1.7 Paranoia 1   Risk Ratio (IV, Random, 95% CI) Subtotals only
1.8 Sedation 2 139 Risk Ratio (IV, Random, 95% CI) 4.47 [0.35, 57.81]
1.9 Participant preference 2 256 Risk Ratio (IV, Random, 95% CI) 4.82 [1.74, 13.36]
1.10 Withdrawal for any reason 1   Risk Ratio (IV, Random, 95% CI) Subtotals only
1.11 Withdrawal due to adverse event 2 276 Risk Ratio (IV, Random, 95% CI) 6.85 [1.96, 23.99]
1.12 Withdrawal due to lack of efficacy 1   Risk Ratio (IV, Random, 95% CI) Subtotals only