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. 2015 Nov 12;2015(11):CD009464. doi: 10.1002/14651858.CD009464.pub2

Comparison 2. Cannabinoid versus other anti‐emetic agent.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
2.1 Absence of nausea 5 258 Risk Ratio (IV, Random, 95% CI) 1.46 [0.67, 3.15]
2.1.1 Prochlorperazine 5 258 Risk Ratio (IV, Random, 95% CI) 1.46 [0.67, 3.15]
2.2 Absence of nausea (subgroup analysis 2) 5   Risk Ratio (IV, Random, 95% CI) Subtotals only
2.2.1 Nabilone 3 141 Risk Ratio (IV, Random, 95% CI) 1.41 [0.33, 6.03]
2.2.2 Dronabinol 2 117 Risk Ratio (IV, Random, 95% CI) 2.38 [0.21, 26.91]
2.3 Absence of vomiting 4 209 Risk Ratio (IV, Random, 95% CI) 1.11 [0.86, 1.44]
2.3.1 Prochlorperazine 4 209 Risk Ratio (IV, Random, 95% CI) 1.11 [0.86, 1.44]
2.4 Absence of vomiting (subgroup analysis 2) 4   Risk Ratio (IV, Random, 95% CI) Subtotals only
2.4.1 Nabilone 2 93 Risk Ratio (IV, Random, 95% CI) 1.55 [0.39, 6.24]
2.4.2 Dronabinol 2 116 Risk Ratio (IV, Random, 95% CI) 1.05 [0.64, 1.71]
2.5 Absence of nausea and vomiting 4 414 Risk Ratio (IV, Random, 95% CI) 2.00 [0.74, 5.38]
2.5.1 Prochlorperazine 4 414 Risk Ratio (IV, Random, 95% CI) 2.00 [0.74, 5.38]
2.6 Absence of nausea and vomiting (subgroup analysis 1) 4   Risk Ratio (IV, Random, 95% CI) Subtotals only
2.6.1 Cannabis naive 2 116 Risk Ratio (IV, Random, 95% CI) 1.10 [0.70, 1.72]
2.6.2 Prior cannabis use 2 298 Risk Ratio (IV, Random, 95% CI) 17.98 [2.44, 132.43]
2.7 Absence of nausea and vomiting (subgroup analysis 2) 4   Risk Ratio (IV, Random, 95% CI) Subtotals only
2.7.1 Nabilone 1 226 Risk Ratio (IV, Random, 95% CI) 17.00 [0.99, 291.06]
2.7.2 Dronabinol 3 188 Risk Ratio (IV, Random, 95% CI) 1.44 [0.62, 3.31]
2.8 Dizziness 9 743 Risk Ratio (IV, Random, 95% CI) 2.54 [1.91, 3.37]
2.8.1 Domperidone 1 38 Risk Ratio (IV, Random, 95% CI) 2.75 [1.06, 7.12]
2.8.2 Prochlorperazine 7 675 Risk Ratio (IV, Random, 95% CI) 2.36 [1.82, 3.07]
2.8.3 Metoclopramide 1 30 Risk Ratio (IV, Random, 95% CI) 12.00 [1.78, 81.06]
2.9 Dysphoria 3 192 Risk Ratio (IV, Random, 95% CI) 7.17 [1.33, 38.84]
2.9.1 Prochloperazine 3 192 Risk Ratio (IV, Random, 95% CI) 7.17 [1.33, 38.84]
2.10 Euphoria 4 358 Risk Ratio (IV, Random, 95% CI) 8.89 [2.05, 38.63]
2.10.1 Domperidone 1 38 Risk Ratio (IV, Random, 95% CI) 5.00 [0.26, 97.70]
2.10.2 Prochlorperazine 2 280 Risk Ratio (IV, Random, 95% CI) 17.97 [2.42, 133.37]
2.10.3 Chlorpromazine 1 40 Risk Ratio (IV, Random, 95% CI) 3.00 [0.13, 69.52]
2.11 'Feeling high' 5 419 Risk Ratio (IV, Random, 95% CI) 5.90 [3.42, 10.17]
2.11.1 Prochlorperazine 4 389 Risk Ratio (IV, Random, 95% CI) 6.18 [3.52, 10.85]
2.11.2 Metoclopramide 1 30 Risk Ratio (IV, Random, 95% CI) 3.00 [0.35, 25.68]
2.12 Hallucinations 2 144 Risk Ratio (IV, Random, 95% CI) 5.39 [0.66, 43.68]
2.12.1 Prochlorperazine 2 144 Risk Ratio (IV, Random, 95% CI) 5.39 [0.66, 43.68]
2.13 Postural hypotension 6 413 Risk Ratio (IV, Random, 95% CI) 2.40 [0.88, 6.53]
2.13.1 Domperidone 1 38 Risk Ratio (IV, Random, 95% CI) 4.00 [0.49, 32.57]
2.13.2 Prochlorperazine 3 305 Risk Ratio (IV, Random, 95% CI) 1.22 [0.52, 2.89]
2.13.3 Metoclopramide 1 30 Risk Ratio (IV, Random, 95% CI) 17.00 [1.07, 270.41]
2.13.4 Chlorpromazine 1 40 Risk Ratio (IV, Random, 95% CI) 7.00 [0.95, 51.80]
2.14 Paranoia 1   Risk Ratio (IV, Random, 95% CI) Subtotals only
2.14.1 Prochlorperazine 1 42 Risk Ratio (IV, Random, 95% CI) 3.00 [0.13, 69.70]
2.15 Sedation 11 1055 Risk Ratio (IV, Random, 95% CI) 1.33 [1.08, 1.64]
2.15.1 Domperidone 1 38 Risk Ratio (IV, Random, 95% CI) 1.22 [0.66, 2.25]
2.15.2 Prochlorperazine 8 947 Risk Ratio (IV, Random, 95% CI) 1.44 [1.18, 1.76]
2.15.3 Metoclopramide 1 30 Risk Ratio (IV, Random, 95% CI) 0.93 [0.73, 1.18]
2.15.4 Chlorpromazine 1 40 Risk Ratio (IV, Random, 95% CI) 1.71 [0.85, 3.44]
2.16 Depression 3 317 Risk Ratio (IV, Random, 95% CI) 0.81 [0.51, 1.28]
2.16.1 Prochlorperazine 3 317 Risk Ratio (IV, Random, 95% CI) 0.81 [0.51, 1.28]
2.17 Participant preference 9 799 Risk Ratio (IV, Random, 95% CI) 2.76 [1.88, 4.03]
2.17.1 Prochlorperazine 7 695 Risk Ratio (IV, Random, 95% CI) 3.24 [2.23, 4.72]
2.17.2 Metoclopramide 1 64 Risk Ratio (IV, Random, 95% CI) 1.20 [0.61, 2.37]
2.17.3 Chlorpromazine 1 40 Risk Ratio (IV, Random, 95% CI) 2.00 [0.83, 4.81]
2.18 Withdrawal for any reason 1   Risk Ratio (IV, Random, 95% CI) Subtotals only
2.18.1 Prochlorperazine 1 42 Risk Ratio (IV, Random, 95% CI) 3.50 [1.38, 8.89]
2.19 Withdrawal due to adverse event 6 740 Risk Ratio (IV, Random, 95% CI) 3.16 [1.26, 7.93]
2.19.1 Domperidone 1 76 Risk Ratio (IV, Random, 95% CI) 3.00 [0.13, 71.40]
2.19.2 Prochlorperazine 5 664 Risk Ratio (IV, Random, 95% CI) 3.90 [1.25, 12.20]
2.20 Withdrawal due to lack of efficacy 2 118 Risk Ratio (IV, Random, 95% CI) 0.97 [0.04, 20.93]
2.20.1 Domperidone 1 76 Risk Ratio (IV, Random, 95% CI) 0.14 [0.01, 2.67]
2.20.2 Prochlorperazine 1 42 Risk Ratio (IV, Random, 95% CI) 3.50 [1.38, 8.89]