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. 2019 Aug 20;33(1):61–69. doi: 10.1093/ajh/hpz139

Figure 1.

Figure 1.

RLV density is increased in male mice with angiotensin II-induced hypertension: (a) systolic blood pressure measures in male mice infused with saline (Control) or Ang II for 2 (M-ANGII-2wk) or 3 (M-ANGII-3wk) weeks. (b) LYVE-1 (lymphatic vessel endothelial hyaluronan receptor 1) immunofluorescence on kidney sections from Control, M-ANGII-2wk, and M-ANGII-3wk mice. Scale bars = 50 μm. Renal interlobular lymphatic density as determined by mean number of LYVE-1+, lumen-containing lymphatic vessels (RLVs) (c) per kidney section and (d) per artery. (e) Gene expression changes in lymphatic vessel markers in kidneys from Control, M-ANGII-2wk, and M-ANGII-3wk mice. (f) Immune cell populations expressed as percentage of CD45+ cells in kidneys of Control, M-ANGII-2wk, and M-ANGII-3wk mice as determined by flow cytometry. Results are expressed as mean ± SEM (n = 6 per group), and statistical analyses were performed with Student’s t test. *P < 0.05 vs. Control mice. Abbreviations: Ang II, angiotensin II; BV, blood vessel; RLV, renal lymphatic vessel.