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Schematic representation of the principal subunits to form IKs channel. Panel A. Relation of the two major subunits (KvLQT1 and MinK) in the cell membrane. Panel B. Formation of the aqueous pore by four subunits. In both panels, numbers indicate the six alpha helical domains traversing the cell membrane. EC and IC mean extracellular and intracellular region, respectively.
