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Effect of IKs block in the presence of elevated sympathetic activity. IKs blocker HMR‐1556 frequency dependently lengthens APD in dog (Panel A) and human (Panel B) ventricular myocytes, when the repolarization reserve is attenuated either by sympathetic stimulation (by isoprenaline, ISO) or combined IKr block with stimulation (by dofetilide + adrenaline, DOF + ADR) [from Refs. 12 (Panel A), Ref. 54 (Panel A) and Ref. 59 (Panel B), used with permission].
