Table 4.

Exposure‐Response Analysis of Plasma Concentrations of Lomitapide and Ketoconazole and ΔΔQTcI

Parameter	Estimate (90% CI)	P Value	Between‐Subject Variation
Intercept (ms)	−0.82 (−1.99;0.35)	0.2504	4.43
Slope for lomitapide (m/ng per mL)	0.0258 (0.0018;0.050)	0.0771	0.0795
Slope for ketoconazole (ms/ng per mL)	0.0013 (0.0010;0.0017)	<0.0001	0.0012
Interaction of lomitapide‐ketoconazole concentrations (ms/square ng per mL)	−0.000006 (−0.000011; −0.000001)	0.0378	0.000010
Residual variability (ms)	7.03