1. Histologic diagnosis group
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Cardiac sarcoidosis is confirmed when histologic analysis of operative or endomyocardial biopsy specimens demonstrates epithelioid granuloma without caseating granuloma |
2. Clinical diagnosis group
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In patients with a histologic diagnosis of extracardiac sarcoidosis, cardiac sarcoidosis is suspected when item (a) and one or more of items (b) though (e) are present |
(a) Complete right bundle branch block, left axis deviation, atrioventricular block, ventricular tachycardia, premature ventricular contraction, or abnormal Q or ST‐T change on the ECG or ambulatory ECG |
(b) Abnormal wall motion, regional wall thinning, or dilatation of the left ventricle |
(c) Perfusion defect by thallium‐201 myocardial scintigraphy or abnormal accumulation by gallium‐67 or technetium‐99m myocardial scintigraphy |
(d) Abnormal intracardiac pressure, low cardiac output, or abnormal wall motion or depressed ejection fraction of the left ventricle |
(e) Interstitial fibrosis or cellular infiltration over moderate grade even if the findings are nonspecific |