Table 1.
Characteristics of Patients Stratified by Presence of Diastolic Dysfunction
| No Diastolic Dysfunction (N = 80) | Diastolic Dysfunction (N = 105) | P‐Value | |
|---|---|---|---|
| Age (years) | 46.3 ± 14.4 | 61.0 ± 13.4 | <0.001 |
| Gender (% male) | 43.8% | 43.8% | 1.000 |
| BMI in kg/m2 (SD) | 27.8 ± 6.3 | 28.6 ± 6.4 | 0.367 |
| Hypertension (%)a | 51.2% | 68.6% | 0.022 |
| Hypercholesterolemia (%)b | 37.5% | 61.0% | 0.002 |
| Diabetes (%)b | 10.0% | 16.2% | 0.280 |
| Smoking | |||
| Current (%) | 20.0% | 17.1% | 0.703 |
| Former (%) | 18.8% | 17.1% | 0.847 |
| Coronary artery disease (%)c | 25.0% | 33.0% | 0.257 |
| Family history CAD (%) | 15.0% | 20.0% | 0.441 |
| Indication for echocardiogram | |||
| Dyspnea (%)d | 12.5% | 24.8% | 0.041 |
| Chest pain (%) | 41.3% | 23.8% | 0.016 |
| Murmur on clinical exam (%) | 3.8% | 13.3% | 0.038 |
| Other (%)e | 42.5% | 38.1% | 0.549 |
Hypertension defined as systolic blood pressure greater than 140 mmHg or diastolic blood pressure greater than 90 mmHg or treatment with antihypertensive medications;
Hypercholesterolemia defined as patient reported history of hypercholesterolemia or diagnosis in the medical record; diabetes defined as patient reported history of diabetes or diagnosis in the medical record;
Coronary artery disease defined as history of greater than 50% coronary artery stenosis through invasive or noninvasive imaging, history of percutaneous coronary intervention, coronary artery bypass grafting, myocardial infarction, or history of abnormal stress consistent with ischemia;
Subjects referred for congestive heart failure were included with Dyspnea;
Other indications included syncope, pericarditis, hypertension, palpitations, and coronary artery disease.