Figure 4.
Restitution prior to torsades de pointes. ECG prior to torsades de points (TdP) event from a 66‐year‐old female subject with coronary artery disease given sotalol (2 mg/kg iv over 20 minute) and beat‐to‐beat QT, R‐R, and TQ interval relationships: (A) 10 second of ECG beats prior to TdP showing mix of sinus (green filled diamonds) and ventricular (purple filled triangles) beats. Relationship of time‐matched response to Cmax (red filled circles; hours 10–12 a.m.), and 105 minute period prior to torsades de pointes event (black hollow triangles; hours noon–1:45 p.m.) showing the (B) QT versus R‐R intervals, (C) QT versus TQ intervals and (D) QT/TQ interval ratio versus R‐R interval; Additionally, the last 10 second of beats from ECG (A) are shown prior to torsades de pointes with the arrow pointing to the last sinus beat.