Table 1.

Characteristics of 15 Prospective Studies of Microvolt T‐Wave Alternans Included in the Meta‐Analysis

Author	Total (n)	Mean Age (y)	Men (%)	Mean EF (%)	ICD (%)	Primary End Points	Etiology	Event Rate	Average FU (m)
Klingenheben et al. 8	107	56	80	28	–	SCD, VT/VF	Isc + Non−Isc	12%	15
Tapanainen et al. 9	246	62	72	45	–	Mortality	Ischemic	1%	14
Grimm et al. 10	263	48	73	30	13	SCD, VT/VF	Nonischemic	14%	52
Hohnloser et al. 11	137	55	77	29	27	SCD, VT/VF	Nonischemic	13%	14
Hohnloser et al. 12	129	63	87	26	–	SCD, CA	Ischemic	9%	24
Sarzi Braga et al. 13	46	59	89	29	–	CD	Isc + Non−Isc	15%	19
Bloomfield et al. 14	549	56	71	25	13	Mortality, VT/VF, ICD shock	Isc + Non−Isc	9%	20
Ikeda et al. 15	1003	64	79	55	–	SCD, CA, VF	Ischemic	2%	32
Baravelli et al. 16	70	65	72	29	21	SCD, HF death, VT/VF, ICD shock	Nonischemic	16%	19
Cantillon et al.*, 17	286	65	78	26	61	Mortality	Isc + Non−Isc	15%	24
Chow et al. 18	768	67	82	27	51	Mortality, ICD shock	Ischemic	21%	27
ALPHA 19	446	59	78	30	8	CD, VT/VF, ICD shock	Nonischemic	6%	19
MASTER20	575	65	84	24	100	Mortality	Ischemic	12%	25
SCD−HeFT substudy21	490	59	76	24	34	SCD, CA, VT/VF, ICD shock	Isc + Non−Isc	15%	30
ABCD22	566	65	84	28	87	SCD, VT/VF, ICD shock	Ischemic	7%	23
Overall	5681	62	79	32	39			10%	26

CA = cardiac arrest; CD = cardiac death; FU = follow‐up; EF = ejection fraction; HF = heart failure; ICD = implantable cardioverter defibrillator; Isc = ischemic; m = months; Non‐Isc = nonischemic; SCD = sudden cardiac death; VT = ventricular tachycardia; VF = ventricular fibrillation; y = years. *Study duration was 38 months, while the mortality rate was based on 24 months results.