Table 2.
Electrical Characteristics of Myocardium in Left Ventricular Hypertrophy. In the Case of Action Potential only Characteristics Related to Depolarization are Reported
| Reference | LVH Model | Finding |
|---|---|---|
| Hicks et al. 30 | Perinephritic hypertension in New Zealand rabbits | No differences in resting membrane potential, upstroke velocity or amplitude of the action potential as compared to control animals |
| Keung and Aronson 31 | Renal hypertension in rat | No difference in action potential |
| Gulch et al. 32 | Coarctation of renal artery in rat | No differences in transmembrane resting potential, upstroke velocity or amplitude of the action potential |
| Scamps et al. 33 | Stenosis of abdominal aorta in rat | No difference in current density |
| Winterton et al. 34 | Aortic constriction in guinea pig | No changes in AP in hypertrophied hearts 50 and 150 days after the operation, a significant conduction delay in 150‐day hypertrophied hearts |
| Brooksby 35 | SHR | No difference in resting membrane difference |
| Kleiman and Houser 36 | Right ventricular hypertrophy in cat | More depolarized resting membrane potential |
| Ryder et al. 37 | Infrarenal aortic constriction in guinea pig | More depolarized resting membrane potential |
| Nordin et al. 38 | Banded ascending aorta in guinea pigs | Lower resting potential |
| Yokoshiki et al. 39 | SHR 12 w | Greater membrane capacitance in SHR, normalized to the control level during regression of LVH produced by captopril treatment |
| Aiello et al. 24 | SHR 16–20 w | Higher membrane capacitance in SHR compared to Wistar rats |
| Cerbai et al. 40 | SHR 12, 72 w | Increase in membrane capacitance |
| Botchway et al. 41 | Aortic constriction in guinea pig | Decreased conduction velocity |
| McIntyre and Fry 42 | Human | Conduction velocity decreased progressively as cell diameter increased both in septal and papillary muscle preparations |
| Cooklin et al. 43 , 44 | Constriction of thoracic aorta in guinea pig | Declined conduction velocity in the later stage (150 days) of LVH in guinea‐pig with constriction of thoracic aorta, with a conduction velocity increase in the earlier stage of LVH (50 days post‐operation), conduction velocity increased |
| Wiegerinck et al. 45 | Pressue‐volume overload in rabbits | Longitudinal and transversal subepicardial conduction velocities higher in animals with heart failure than in controls, transmural conduction velocity unchanged |