Table 2.
QT Prolongation at 15 Minutes, Maximum QT Prolongation and Tmax After Ibutilide Infusion
| Method | Baseline QT (ms) | 0.25 mg Ibutilide | 0.5 mg Ibutilide | ||||
|---|---|---|---|---|---|---|---|
| QT at 15 minutes (ms) | Max QT (ms) | Tmax minutes | QT at 15 minutes (ms) | Max QT (ms) | Tmax minutes | ||
| Lead II | 376.4 ± 5.3 | 38.6 ± 4.0 | 40.1± 4.4 | 21.0 | 53.6 ± 3.0 | 54.6 ± 2.7 | 18.0 |
| 12‐SIM | 387.5 ± 5.3 | 35.4 ± 3.4 | 38.2 ± 4.1 | 22.5 | 56.5 ± 5.5 | 56.6 ± 5.5 | 16.5 |
| 3‐LEAD | 376.9 ± 5.0 | 43.2 ± 4.6 | 43.2 ± 4.6 | 15 | 63.4 ± 4.2 | 64.0 ± 4.1 | 16.5 |
| AUT | 394.7 ± 4.7 | 31.1 ± 6.5 | 36.1 ± 5.5 | 26.7a | 52.9 ± 5.7 | 58.9 ± 3.3 | 25.5b |
Values are mean ± standard error. QT △= change of QT interval; Tmax= the time at which the maximum QT interval was recorded.
aExcluding one subject with Tmax= 4 hours after start of infusion.
bExcluding one subject with Tmax= 24 hours after start of infusion.