Skip to main content
. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Thromb Haemost. 2019 Feb 7;119(5):716–725. doi: 10.1055/s-0039-1678694
What is known on this topic What this paper adds

  1. The MEF2C transcription factor has been associated with platelet count and volume in Genome-wide Association Studies

  2. MEF2C deficient mice have defects in platelet production

  3. High MEF2C levels have been associated with worse outcomes in pediatric Acute Myeloid Leukemia

  1. AGO3, MOV10, RBBP5, HDAC1, and WASF2, genes annotated as regulating megakaryopoiesis, have been identified as MEF2C targets.

  2. rs200234178 and rs34845073, two single nucleotide polymorphisms linked to a noncoding GWAS-identified MEF2C variant, alter transcriptional regulation.