Table 1.
Parameters | F1‐1 | F1‐2 | F1‐3 | F2‐4 | F2‐5 | F2‐6 | F2‐7 | F3‐8 | F3‐9 | F3‐10 | Control Population |
---|---|---|---|---|---|---|---|---|---|---|---|
Age | 35 | 31 | 6 | 51 | 39 | 49 | 21 | 19 | 50 | 82 | 51 ± 6 years |
Sex | M | F | F | M | M | M | M | M | M | M | M: 48.3% |
QT | 320 | 240 | 240 | 300 | 320 | 320 | 320 | 280 | 310 | 280 | — |
QTc | 292* | 262* | 279* | 335* | 345* | 358* | 330* | 313* | 307* | 280* | 405 (399.2–412.2) |
Mutation | HERG | HERG | HERG | HERG | HERG | HERG | HERG | Not defined | Not defined | Not defined | |
Symptoms | Syncope | Pre‐syncope | Aborted SCD | Syncope | Syncope | —— | —— | Aborted SCD | VT | —— | |
T‐wave amplitude V2 | 1.89* | 0.71* | 0.39* | 1.19* | 1.03* | 1.43* | 1.11* | 1.30* | 1.05* | 0.61* | 0.50 (0.44–0.55) |
TCRT | 0.85* | −0.44* | −0.21* | 0.15* | −0.22* | 0.26 | 0.63* | −0.13* | −0.95* | 0.84* | 0.36 (0.25–0.47) |
Width | 1.48 | 0.59 | 0.39 | 0.73 | 0.54 | 0.87 | 0.61 | 0.75 | 0.56 | 0.57 | 3.98 (0–10.65) |
Height | 0.24* | 0.30* | 0.18* | 0.44* | 0.26* | 0.26* | 0.18* | 0.23* | 0.28* | 0.22* | 0.14 (0.13–0.16) |
Ratio | 0.16* | 0.50 | 0.47 | 0.60* | 0.48 | 0.30* | 0.29* | 0.30* | 0.50 | 0.39 | 0.43 (0.32–0.53) |
TWLD | 36 | 35* | 41* | 36 | 35* | 35* | 36 | 33* | 39* | 34* | 37 (36–38) |
M = male; F = female; SCD = sudden cardiac death; VT = ventricular tachycardia; QT and QTc (ms); TCRT = total cosine R‐to‐T; Width = width of the T‐wave loop; Height = height of the T‐wave loop; Ratio = ratio of the T‐wave loop height and width; TWLD = T‐wave loop dispersion. *= Value outside of the control population 99% confidence interval.