Table 4.
Time‐Specific Mean Values ± (SD) of Uncorrected and Heart Rate Corrected QT Maximum Intervals, QT Minimum Intervals and Average QT Intervals Using All 12‐Leads Measured Every Fourth Hour in 10 Consecutive Minutes Are Presented and at the Bottom Line of Each Section the P‐Value for Mixed Model Analysis for Circadian Variation Is Presented
| Study Group (N) | QT Maximum ms | Qtc Maximum ms | QT Minimum ms | Qtc Minimum ms | Average QT Intervals ms | Average QTc Intervals ms |
|---|---|---|---|---|---|---|
| Healthy (54) | ||||||
| 0400–0500 | 416.81 ± (31.11) | 417.08 ± (28.16) | 373.57 ± (29.54) | 373.87 ± (28.03) | 400.18 ± (28.13) | 400.47 ± (25.71) |
| 0800–0900 | 377.77 ± (30.92) | 417.00 ± (26.49) | 342.15 ± (31.10) | 377.49 ± (25.97) | 362.26 ± (29.87) | 399.46 ± (23.27) |
| 1200–1300 | 365.58 ± (25.56) | 413.95 ± (24.91) | 333.59 ± (23.56) | 377.66 ± (22.19) | 350.45 ± (23.83) | 396.69 ± (20.90) |
| 1600–1700 | 371.03 ± (26.85) | 414.45 ± (25.06) | 337.84 ± (28.35) | 377.01 ± (22.46) | 355.80 ± (26.24) | 397.24 ± (21.29) |
| 2000–2100 | 379.09 ± (26.56) | 419.69 ± (25.30) | 345.55 ± (23.54) | 382.49 ± (21.50) | 363.55 ± (23.72) | 402.44 ± (21.38) |
| 0000–0100 | 396.89 ± (29.17) | 417.55 ± (27.52) | 361.02 ± (27.04) | 379.81 ± (25.92) | 381.90 ± (27.25) | 401.75 ± (25.35) |
| Circadian variation | ||||||
| P‐value | <0.0001 | NS | <0.0001 | <0.005 | <0.0001 | <0.005 |
| CAD (29) | ||||||
| 0400–0500 | 426.25 ± (30.48) | 435.94 ± (24.56) | 385.88 ± (26.44) | 394.80 ± (23.00) | 408.72 ± (26.72) | 418.09 ± (21.79) |
| 0800–0900 | 397.29 ± (35.15) | 436.04 ± (28.12) | 356.52 ± (31.90) | 390.98 ± (20.72) | 377.76 ± (32.33) | 414.47 ± (22.66) |
| 1200–1300 | 382.24 ± (32.91) | 427.85 ± (25.90) | 348.01 ± (31.81) | 389.21 ± (21.40) | 365.91 ± (31.00) | 409.44 ± (21.84) |
| 1600–1700 | 383.29 ± (29.73) | 432.81 ± (29.97) | 346.94 ± (29.36) | 391.34 ± (23.88) | 364.85 ± (28.37) | 411.71 ± (24.27) |
| 2000–2100 | 393.12 ± (28.63) | 430.74 ± (24.68) | 358.15 ± (26.69) | 392.34 ± (21.73) | 376.07 ± (26.23) | 412.00 ± (20.88) |
| 0000–0100 | 410.76 ± (33.18) | 434.96 ± (26.67) | 370.28 ± (27.69) | 392.28 ± (24.13) | 393.22 ± (28.80) | 416.40 ± (21.78) |
| Circadian variation | ||||||
| P‐value | <0.0001 | <0.05 | <0.0001 | NS | <0.0001 | <0.005 |
| HF (29) | ||||||
| 0400–0500 | 432.45 ± (41.48) | 462.75 ± (41.14) | 381.48 ± (43.92) | 407.77 ± (41.20) | 408.79 ± (41.15) | 437.24 ± (39.27) |
| 0800–0900 | 415.03 ± (48.24) | 469.50 ± (43.49) | 363.01 ± (46.06) | 410.09 ± (37.39) | 388.97 ± (46.44) | 439.68 ± (38.05) |
| 1200–1300 | 395.58 ± (40.24) | 460.46 ± (40.18) | 348.78 ± (38.88) | 405.76 ± (37.58) | 372.46 ± (38.05) | 433.43 ± (36.56) |
| 1600–1700 | 413.49 ± (42.92) | 464.16 ± (39.30) | 363.93 ± (39.54) | 408.21 ± (33.40) | 389.72 ± (40.46) | 437.20 ± (33.72) |
| 2000–2100 | 411.77 ± (42.85) | 466.73 ± (41.91) | 362.77 ± (41.38) | 411.02 ± (39.72) | 387.57 ± (40.18) | 439.25 ± (38.42) |
| 0000–0100 | 428.69 ± (44.14) | 465.85 ± (39.19) | 377.18 ± (46.53) | 409.44 ± (40.18) | 404.11 ± (43.41) | 438.94 ± (37.11) |
| Circadian variation | ||||||
| P‐value | <0.0001 | NS | <0.0001 | NS | <0.0001 | NS |