Table 3.
Clinical Characteristics of MADIT Patients with and without Frequent VPBs (>3 per 10 minutes)
| Clinical Variables | VPBs ≤ 3 (n = 476) | VPBs > 3 (n = 408) |
|---|---|---|
| Mean age at randomization (years) | 61 | 65** |
| Patients at age ≥ 65 years | 39% | 53%** |
| Median MI months before enrollment | 43 | 65** |
| Mean heart rate | 67 | 72** |
| QRS > 0.12 seconds | 25% | 34%** |
| Coronary bypass surgery | 53% | 61%* |
| Hypertension requiring treatment | 52% | 59%* |
| Left bundle branch block | 15% | 19% |
| Female | 18% | 15% |
| Mean LVEF (%) | 24% | 23% |
| CHF NYHA Classification ≥ II | 63% | 63% |
| Diabetes | 35% | 35% |
| BUN > 25 | 25% | 26% |
| Medication at time of Holter | ||
| Beta‐blockers | 71% | 55%** |
| Diuretics | 67% | 75%* |
| ACE‐inhibitors | 78% | 73%* |
| Digitalis | 55% | 53% |
| Statins | 65% | 61% |
*P < 0.05; **P < 0.01 when comparing two groups.