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. 2019 Dec 26;14(12):e0226553. doi: 10.1371/journal.pone.0226553

Fig 4. ACE conformation in lung cancer (conformational fingerprinting of ACE).

Fig 4

ACE activity was precipitated by 17 different mAbs from five individual homogenates of tumor lung tissues and their morphologically normal lung counterparts. Immunoprecipitated ACE activity is presented as a normalized value (Tumor/Normal ratio), to highlight differences in immunoprecipitation pattern of ACE from different homogenates by different antibodies. ACE activity in these 10 homogenates was quantified before immunocapture and ZPHL/HHL ratio was calculated and presented as a percentage of a value for morphologically normal tissues–values on the right side of the data for each patient. Data presented as a mean of at least 2–3 independent experiments in duplicates. Ratio increased more than 20% are highlighted with orange, more than 50% -with brown and more than 100%—with red. Bars highlighted with yellow- ratio decreased more than 20%, with blue—decreased more than 50%. Bars were highlighted if values were statistically significant (* p<0.05).