Table 7. Top hits from the TDT (transmission disequilibrium test) genome-wide association study.
Locus | All mothers vs. fathers | MI mothers vs. fathers | MII mothers vs. fathers | MI mothers vs. MII mothers | TDT |
---|---|---|---|---|---|
rs3802065 | P = 0.0144 | P = 0.0066 | P = 0.0318 | P = 0.00859 | P = 4.84e-07 |
rs2867076 | P = 0.0164 | P = 0.0227 | P = 0.0081 | P = 0.00904 | P = 1.05e-06 |
rs7451700 | P = 0.0186 | P = 0.0169 | P = 0.0544 | P = 0.0195 | P = 1.71e-06 |
rs7389783 | P = 0.0421 | P = 0.0397 | P = 0.00488 | P = 0.00741 | P = 1.93e-06 |
rs17769147 | P = 0.182 | P = 0.152 | P = 0.0738 | P = 0.0624 | P = 2.06e-06 |
rs201634098 | P = 0.00592 | P = 0.00385 | P = 0.0722 | P = 0.015 | P = 3.52e-06 |
chr23:154539980 | NA | NA | NA | NA | P = 3.63e-06 |
rs74615884 | P = 0.0801 | P = 0.037 | P = 0.0167 | P = 0.00236 | P = 3.73e-06 |
rs158866 | P = 0.036 | P = 0.00582 | P = 0.0103 | P = 0.0102 | P = 3.77e-06 |
rs1187600 | P = 0.0553 | P = 0.0636 | P = 0.204 | P = 0.156 | P = 6.25e-06 |
rs55743346 | P = 0.0514 | P = 0.0371 | P = 0.0834 | P = 0.0234 | P = 7.34e-06 |
rs183199067 | P = 0.0131 | P = 0.00285 | P = 0.0396 | P = 0.0254 | P = 9.55e-06 |
rs140022090 | P = 0.0163 | P = 0.00733 | P = 0.0538 | P = 0.00493 | P = 9.55e-06 |
rs34518363 | P = 0.00538 | P = 0.00186 | P = 0.049 | P = 0.0394 | P = 9.55e-06 |
rs6681167 | P = 0.0358 | P = 0.0505 | P = 0.0648 | P = 0.0377 | P = 9.58e-06 |
Suggestive associations (p < 10−5) are recorded (highlighted cells). For each such locus, the most significant association within 20kb is recorded for each of the other four genome-wide analyses. Rows are ordered by significance. (MI: meiosis I; MII: meiosis II; P: p-value.)