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. 2019 Dec 9;11(23):11673–11685. doi: 10.18632/aging.102571

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Copyright © 2019 Zou et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited..

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Differential expression gene analysis. (A) RBM8A is down-regulated in AD (P= 1.620e−19, 310 AD patients and 157 normal people's postmortem prefrontal cortex samples are contained). (B) Volcano plot of the AD-control, red represents up-regulated genes, blue represents down-regulated genes, and black represents no significantly differentially expressed genes. (C) Volcano plot of the RBM8A-low/high, blue represents down-regulated genes, and black represents no significantly differentially expressed genes. (D) A heatmap of 25 most up-regulated and 25 most down-regulated genes.