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. 2019 Dec 4;11(23):10839–10860. doi: 10.18632/aging.102488

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Copyright © 2019 Chen et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Hypoxia-mediated upregulation of HIF-2α expression activates mTOR signalling pathways. (A) Pearson correlation analysis of the correlation between HIF-2α expression and relative genes in the patients with liver hepatocellular carcinoma (LIHC) from the TCGA database (http://gepia.cancer-pku.cn). (B) Western blot analysis of HIF-2α expression and expression of PI3K-AKT-mTOR pathway factors in HCC and steatotic HCC under hypoxic conditions. β-Actin was used as the loading control. Densitometric analyses of the band intensity ratios for HIF-2α/β-actin, PI3K/β-actin, p-GSK3β/GSK3β, p-AKT/AKT and p-mTOR/mTOR.