Table 6. Univariate and multivariate Cox regression analysis of the 3-CpG prognostic methylation classifier and clinical factors with overall survival of EAC.
| Risk factor | Univariate Cox | Multivariate Cox | |||
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| Age (> 60 vs ≤60) | 0.986(0.962-1.009) | 0.2283 | 0.986(0.960-1.014) | 0.3275 | |
| Gender (male vs female) | 0.847(0.299-2.400) | 0.7553 | 0.552(0.158-1.928) | 0.3520 | |
| BMI (> 25 vs ≤25) | 1.019(0.983-1.058) | 0.3056 | 1.063(1.015-1.112) | 0.0093 | |
| Smoking (yes vs no) | 1.133(0.606-2.117) | 0.6953 | 1.317(0.681-2.547) | 0.4138 | |
| Alcohol use (yes vs no) | 0.516(0.281-0.948) | 0.0330 | 0.616(0.304-1.245) | 0.1771 | |
| Tumor stage (III/IV vs I/II) | 2.238(1.151-4.351) | 0.0176 | 2.028(0.930-4.420) | 0.0753 | |
| Methylation classifier (high vs low risk) | 5.661(2.639-12.145) | < 0.0001 | 5.164(2.199-12.130) | 0.0002 | |