Figure 2.

CBC activates CB₂, but not CB₁, receptors (a) Concentration‐response curves of CP55,940, THC, and CBC in AtT20‐CB1 cells (n = 5). Results are expressed as mean ± SEM after normalization to 1‐μM CP55,940 hyperpolarization. (b) Representative traces of changes in fluorescence, due to CBC and 1‐μM CP55,940‐induced hyperpolarization in AtT20‐CB1 cells. Drugs were added after 120 s of baseline reading and read over 300 s. (c) Concentration‐response curves of CP55,940, THC, and CBC in AtT20‐CB2 cells (n = 5). Results are expressed as mean ± SEM after normalization to 1‐μM CP55,940 hyperpolarization. (d) Representative traces of changes in fluorescence, due to CBC and 1‐μM CP55,940‐induced hyperpolarization in AtT20‐CB2 cells. Drugs were added after 120 s of baseline reading and read over 300 s