Table 1.
Significantly expressed miRNAs in IFNγ/EV-endMSCs.
| miRNA | logFC | p-value | FDR |
|---|---|---|---|
| hsa-miR-196b-5p | 1.07 | <0.0001 | 0.00019 |
| hsa-miR-1246 | −1.12 | <0.0001 | 0.00616 |
| hsa-miR-92a-3p | −1.34 | 0.0001 | 0.01187 |
| hsa-miR-150-5p | −1.87 | 0.00023 | 0.02956 |
| hsa-miR-299-5p | −4.32 | 0.00055 | 0.05749 |
| hsa-miR-146a-5p | −1.88 | 0.00114 | 0.09818 |
| hsa-miR-378a-3p | −1.45 | 0.00763 | 0.49394 |
| hsa-miR-27a-5p | 0.99 | 0.01104 | 0.61100 |
| hsa-miR-484 | −2.12 | 0.01614 | 0.61698 |
| hsa-miR-409-3p | −0.80 | 0.01816 | 0.61698 |
| hsa-miR-490-3p | 1.15 | 0.01853 | 0.61698 |
| hsa-miR-30c-5p | −0.87 | 0.02242 | 0.61698 |
| hsa-miR-10b-5p | 0.34 | 0.02252 | 0.61698 |
| hsa-miR-574-5p | 1.25 | 0.02263 | 0.61698 |
| hsa-miR-486-5p | −1.25 | 0.02619 | 0.64869 |
| hsa-miR-17-5p | 1.20 | 0.02630 | 0.64869 |
| hsa-miR-376c-3p | 0.96 | 0.03618 | 0.67893 |
| hsa-miR-146b-5p | −0.59 | 0.03790 | 0.67893 |
miRNA expression level is expressed as log fold change (logFC) between IFNγ/EV-endMSCs (n = 4), and EV-endMSCs groups (n = 4). The comparison of expression levels between groups led to 18 significantly altered microRNAs (p <0.05), 4 of them presenting 5% FDR (bold highlighted) based on Benjamini-Hochberg FDR adjusted p-values. The full list of differentially expressed miRNAs is described in Supplementary Table 9. EV-endMSCs: Extracellular Vesicles derived from endometrial MSCs; FDR: False Discovery Rate; IFNγ/EV-endMSCs: Extracellular Vesicles derived from IFNγ-primed endometrial MSCs.