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. 2019 Dec 20;13:1374. doi: 10.3389/fnins.2019.01374

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Copyright © 2019 Shi, Yan, Ding, Zhou, Qian, Wang, Gong, Zhang, Zhang, Zhao, Wen, Chen, Deng, Luo, Xiong and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bilateral ablation of AAF impairs animal’s categorization of dangerous and safe cue. (A) A representative tonotopic map in the left auditory cortex. Color dot shows the characteristic frequency (CF) at recording site. A1, primary auditory cortex; AAF, anterior auditory field; R, rostral; D, dorsal. (B) Six tonal receptive fields shown in A. (C) Ablation sites in auditory cortex. Images are modified from “The rat brain in stereotaxic coordinates (6th Edition).” Scale bar, 1 mm. (D) Schematic drawing of training and testing protocol. (E) Freezing duration to sound cues during training session in the first day. (F) Comparison of freezing duration between AAF ablated rats (AAF ablated) and normal rats (control). ^∗∗p < 0.01, paired t-test; ^∗∗∗p < 0.001, t-test.