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. 2019 Dec 20;10:1515. doi: 10.3389/fphar.2019.01515

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Copyright © 2019 Lin, Zhou, Hou, Li, Qiao, Wang, Huang and Niu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Safety evaluation of chronic FGF1 administration. (A, B) Evidence of liver injury as determined by serum activities of liver enzymes Alanine transaminase and aspartate transaminase (ALT and AST). (C–E) Real-time polymerase chain reaction (RT-PCR) analysis of hepatic mRNA levels of the proliferation markers including Ki-67, AFP, and PCNA in C57BL/6J mice after chronic treatment, data was normalized to actin mRNA levels and expressed as fold change relative to control group (PBS-treated mice) (F) immune-histochemical staining using PCNA. Data are presented as mean ± SEM; *P < 0.05; ***P < 0.001; versus control group; n = 8.