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. 2019 Dec 20;12:316. doi: 10.3389/fnmol.2019.00316

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Copyright © 2019 Korrapati, Taukulis, Olszewski, Pyle, Gu, Singh, Griffiths, Martin, Boger, Morell and Hoa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis with Pharos reveals druggable gene targets in the Esrrb and Bmyc regulons. Pharmacologic drug classes are shown in lower left corner including enzyme, G-protein coupled receptor (GPCR), ion channel, receptor, and kinase. FDA-approved drugs are classified as inhibitors (red), activators (green), or unknown (gray). (A) Druggable gene targets in the Esrrb regulon. Analysis identified 13 druggable genes with 25 FDA-approved drugs. (B) Druggable gene targets in the Bmyc regulon. Analysis identified 13 druggable genes with 68 FDA-approved drugs. Drugs for Adrb2 and Maoa genes are provided in Supplementary Figure S9.