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. Author manuscript; available in PMC: 2019 Dec 27.
Published in final edited form as: J Med Chem. 2019 Dec 5;62(24):11232–11259. doi: 10.1021/acs.jmedchem.9b01411

Figure 1.

Figure 1.

An overlay of WDR5 bound to MYC and MLL peptides (PDB: 4Y7R & 3EG6 respectively). A) Visualization of the MYC MbIIIb peptide bound to a cleft of WDR5, referred to as the ‘WBM’ binding site; B) The MLL1 peptide binds on the reverse face of WDR5 with an arginine residue deep into the ‘WIN’ site binding pocket.