Table 4.
Supportive Care Therapy | Sleep Treatments | |||||||
---|---|---|---|---|---|---|---|---|
Pre Treatment Week 0 M ± SD |
PE Completed Week 6 M ± SD |
PE + 5 weeks SCT Week 11 M ± SD |
PE + 12 weeks SCT Week 18 M ± SD |
Pre Treatment Week 0 M ± SD |
PE Completed Week 6 M ± SD |
PE + IRT Week 11 M ± SD |
PE + IRT+CBTI Week 18 M ± SD |
|
PTSD, Depression and Quality of Life | n = 11 | n = 11 | n = 8 | n = 8 | n = 12 | n = 12 | n = 6 | n = 7 |
CAPS Total score | 70.09 ± 15.56 | 61.36 ± 19.50 A | 55.13 ± 23.44 | 52.38 ± 18.52 A | 74.08 ± 13.70 | 53.33 ± 19.38 A | 44.33 ± 19.05 A | 37.57 ± 20.97 AB |
Re-experiencing | 19.45 ± 4.78 | 20.27 ± 5.62 | 17.38 ± 6.85 | 16.75 ± 6.78 | 19.42 ± 5.90 | 16.92 ± 6.13 | 12.83 ± 9.89 | 13.17 ± 8.13 |
Avoidance/numbing | 25.82 ± 9.09 | 18.54 ± 11.30 A | 14.88 ± 12.63 A | 14.00 ± 8.38 A | 30.42 ± 6.14 | 17.83 ± 9.45 A | 14.67 ± 7.12 A | 12.00 ± 8.32 A |
Hyperarousal | 24.82 ± 4.40 | 22.54 ± 4.68 | 22.88 ± 5.84 | 21.63 ± 5.43 D | 24.25 ± 4.81 | 18.58 ± 6.13 A | 16.83 ± 7.22 A | 12.00 ± 9.14 ABCD |
CAPS without Sleep Items | 56.91 ± 15.59 | 49.45 ± 19.00 | 42.63 ± 22.50 | 40.63 ± 17.39 A | 61.67 ± 12.99 | 42.17 ± 18.66 A | 35.17 ± 16.03 | 31.17 ± 19.26 A |
PCL Total score | 58.27 ± 9.73 | 45.80 ± 16.73^ | 40.75 ± 14.54 A | 40.38 ± 14.17 A | 58.92 ± 9.27 | 39.75 ± 14.58 A | 33.71 ± 12.43 A | 34.43 ± 16.15 A |
PHQ | 14.91 ± 5.56 | 11.64 ± 6.67 | 10.25 ± 5.97 | 11.75 ± 6.98 | 17.08 ± 5.57 | 9.42 ± 5.37 A | 6.33 ± 4.59 A | 7.29 ± 5.77 A |
VR-36 Physical Component | 43.71 ± 11.21 | 43.58 ± 10.88 | 44.32 ± 7.96 | 43.20 ± 9.93 | 46.07 ± 11.24† | 45.35 ± 10.28 | 47.23 ± 7.79# | 49.24 ± 7.54 |
VR-36 Mental Component | 31.70 ± 13.26 | 38.28 ± 12.72 | 40.33 ± 11.61 | 42.27 ± 11.66 | 30.52 ± 8.20† | 40.04 ± 11.28 A | 45.83 ± 10.75#A | 42.63 ± 11.26 A |
Sleep Diary | n = 11 | n = 10 | n = 8 | n = 8 | n = 12 | n = 11 | n = 6 | n = 7 |
Sleep Efficiency* | 76.51 ± 10.07 | 81.74 ± 10.55 | 74.70 ± 17.75 | 74.61 ± 11.59 D | 73.33 ± 12.11 | 78.77 ± 9.79 | 82.82 ± 8.29 | 91.29 ± 4.89 CDY |
Total number of nightmares* | 6.64 ± 4.20 | 4.10 ± 3.84 A | 5.88 ± 6.88 | 4.50 ± 6.78 | 6.50 ± 3.94 | 4.00 ± 3.77 A | 3.67 ± 3.27 | 2.14 ± 2.73 |
Total Sleep Time (minutes) | 357.36 ± 99.82 | 361.57 ± 106.82 | 332.45 ± 135.32 | 304.12 ± 103.10 | 321.42 ± 57.85 | 324.45 ± 70.40 | 365.26 ± 65.68 A | 326.29 ± 91.15 |
Sleep Latency (minutes)* | 55.93 ± 37.80 | 32.24 ± 24.12 | 38.02 ± 17.01 | 39.54 ± 18.66 | 35.76 ± 29.83 | 30.33 ± 17.57 | 31.79 ± 18.38 | 21.37 ± 19.52 C |
Wake After Sleep Onset (minutes)* | 52.24 ± 16.60 | 42.70 ± 24.00 | 50.58 ± 29.01 | 51.31 ± 23.86 | 85.54 ± 57.10 | 59.27 ± 44.22 | 42.15 ± 32.09 AB | 31.12 ± 39.01 BCYX |
Highest nightmare rating* | 8.00 ± 1.34 | 5.30 ± 2.98 A | 6.63 ± 2.39 | 5.50 ± 3.42 | 7.17 ± 2.48 | 6.27 ± 3.29 | 5.33 ± 3.08X | 4.57 ± 3.36 |
Night-to-night variability: SL* | 40.15 ± 25.02 | 18.95 ± 14.02 A | 20.89 ± 13.75 A | 29.84 ± 20.18 | 30.19 ± 38.54 | 15.90 ± 13.36 | 15.88 ± 13.11 | 14.61 ± 27.23 |
Night-to-night variability: WASO* | 41.21 ± 24.16 | 34.92 ± 31.64 | 40.15 ± 25.41 | 34.29 ± 19.15 | 72.21 ± 47.43 | 46.26 ± 27.06 | 25.71 ± 16.91 | 20.67 ± 12.35 AB |
Night-to-night variability: TST* | 91.72 ± 36.32 | 102.49 ± 51.03 | 111.45 ± 69.03 | 115.91 ± 84.97 | 133.55 ± 64.37 | 82.06 ± 37.55 A | 65.42 ± 29.66 | 57.54 ± 43.14 A |
Night-to-night variability: SE* | 12.26 ± 7.67 | 10.28 ± 10.11 | 14.43 ± 14.52 | 14.88 ± 4.98 | 16.95 ± 6.75 | 12.45 ± 5.23 | 7.86 ± 5.20 A | 8.02 ± 8.40 |
Actigraphy | n = 9 | n = 8 | n = 6 | n = 6 | n = 9 | n = 10 | n = 7 | n = 7 |
Total Sleep Time (minutes) | 330.65 ± 39.70 | 344.56 ± 49.74 | 339.89 ± 25.63 | 350.19 ± 37.90 | 365.21 ± 62.08 | 334.06 ± 44.66 | 354.94 ± 65.24 | 283.75 ± 65.20 |
Wake After Sleep Onset | 55.18 ± 29.12 | 55.00 ± 25.78 | 47.31 ± 21.92 | 57.94 ± 30.46 | 44.22 ± 9.07 | 39.58 ± 16.44 | 43.32 ± 18.61 | 53.76 ± 30.02 |
Sleep Efficiency | 68.03 ± 8.69 | 85.89 ± 6.67 A | 75.68 ± 5.99 B | 75.45 ± 7.11 B | 75.48 ± 11.63 | 89.54 ± 3.90 A | 76.35 ± 9.49 B | 69.57 ± 15.96 B |
Time in Bed | 385.83 ± 58.43 | 402.77 ± 60.43 | 387.20 ± 36.18 | 408.13 ± 61.47 D | 410.30 ± 60.59 | 373.64 ± 51.55 | 398.26 ± 62.03 | 337.56 ± 48.37 D |
Retrospective Sleep Measures | n = 11 | n = 11 | n = 8 | n = 8 | n = 12 | n = 12 | n = 5 | n = 7 |
Insomnia Severity Index | 18.73 ± 4.10 | 16.36 ± 5.54 | 18.50 ± 5.35 D | 16.75 ± 6.02 | 18.75 ± 3.98 | 14.42 ± 5.84 A | 9.20 ± 6.26 DX | 9.71 ± 7.13 ABC |
Pittsburgh Sleep Quality Index | 15.09 ± 3.73 | 13.36 ± 2.06 | 14.75 ± 1.67 D | 13.13 ± 3.31 D | 14.75 ± 3.05 | 11.50 ± 2.58 A | 9.60 ± 4.04 DX | 7.71 ± 4.50 ABCD |
Pittsburgh Sleep Quality Index-Addendum | 10.82 ± 2.86 | 8.00 ± 3.66 A | 8.75 ± 4.40 | 14.38 ± 5.76 ABC | 8.42 ± 3.92 | 7.92 ± 4.19 | 4.60 ± 4.39B | 8.29 ± 5.59 |
Primary outcome variables are presented in boldface.
used non-parametric, Mann-Whitney U and Wilcoxon signed-rank test;
different from week 0 of same condition;
different from week 6 measure of same condition;
different from week 11 of same condition;
different from same week of different condition;
change from week 6 is significantly greater than SCT;
change from week 11 is significantly greater than SCT;
n = 11;
n = 6;
n = 10;
all significance designation based on p<.05.