Table 2.
Comparison between patients who developed HCC and those who did not
| Variable | Patients who developed HCC (n=41, 41.4%) | Patients who did not develop HCC (n=58, 58.6%) | P-value |
|---|---|---|---|
| Demographic variables | |||
| Age (years) | 59 (54–63) | 57 (50–65) | 0.226 |
| Male gender | 30 (73.2) | 42 (72.4) | 0.934 |
| Hypertension | 12 (29.3) | 11 (19.0) | 0.232 |
| Diabetes | 11 (26.9) | 11 (19.0) | 0.354 |
| Body mass index (kg/m2) | 24.1 (22.4–26.8) | 25.1 (22.8–26.4) | 0.797 |
| Liver cirrhosis | 13 (31.7) | 31 (53.4) | 0.032 |
| On-going antiviral therapy | 28 (68.3) | 34 (58.6) | 0.327 |
| Previous HCC history | 27 (65.9) | 20 (34.5) | 0.002 |
| Laboratory variables | |||
| HBeAg positive | 11 (26.8) | 18 (31.0) | 0.651 |
| HBV DNA (IU/mL) | 20.0 (20.0–126.5) | 29.5 (20.0–52,150.0) | 0.399 |
| Alpha-fetoprotein (ng/mL) | 6.8 (2.6–14.6) | 3.6 (2.0–7.1) | 0.790 |
| Aspartate aminotransferase (IU/L) | 29 (25–40) | 36 (28–51) | 0.031 |
| Alanine aminotransferase (IU/L) | 26 (20–39) | 29 (21–42) | 0.044 |
| Total bilirubin (mg/dL) | 0.9 (0.6–1.1) | 1.0 (0.7–1.4) | 0.105 |
| Serum albumin (g/dL) | 4.2 (3.9–4.6) | 4.2 (3.9–4.5) | 0.526 |
| Platelet count (109/L) | 130 (90–163) | 120 (89–164) | 0.709 |
| Tumor variables | |||
| Maximal size (mm) | 10 (8–15) | 11 (9–16) | 0.417 |
| Arterial enhancement | 6 (14.6) | 10 (17.2) | 0.728 |
| T2 hyperintensity | 13 (31.7) | 11 (19.0) | 0.145 |
| Diffusion restriction | 13 (31.7) | 10 (17.2) | 0.093 |
| Prediction models | |||
| CU-HCC | 3 (3–18) | 15 (3–18) | 0.285 |
| REACH-B | 8 (7–11) | 8 (7–10) | 0.991 |
| RADCT score | 119 (95–145) | 107 (87–124) | 0.013 |
Variables are expressed as median (interquartile range) or n (%).
HCC, hepatocellular carcinoma; HBeAg, hepatitis B virus envelope antigen; HBV, hepatitis B virus; DNA, deoxyribonucleic acid; REACH-B, risk estimation for hepatocellular carcinoma in chronic hepatitis B; CU, Chinese university; RADCT, a risk prediction model for the development of hepatocellular carcinoma from indeterminate nodules detected on computed tomography.